Rmath's 4-factor Method - 'from the top'

[Mitch44]

Its effective by the settings chosen and perhaps it could be by the track or few tracks chosen for the study.

Also something else that just dawned on me and perhaps your correct is because the way those lines are weighted and where the abnormal variant occurs it has little or no effect unless its the last line. 75 % chance that its not the last line.

Within the all the other readouts etc. Within RDSS for the line chosen that line is not weighted so therefore has more effect or is 100% effected by the line chosen , therefore the default setting are the correct setting to choose for all other readouts. With the CSR there a 75 % chance of not being L1 so not impacted as much due to weighting. Ideally if the high variant or abnormal one is L4 is the even better.

IMO and to each their own while the effect is lessened by which line it falls in of the four,the high variant or abnormal one is due to weighting, I still think its an improvement and more efficient to use the default settings.

Mitch44